Isaiah the Prophet
It is stated in the first verse of the Book of Isaiah that he prophesied during the reigns of Uzziah (or Azariah), Jotham, Ahaz, and Hezekiah, the kings of Judah (Isaiah 1:1). Uzziah reigned fifty-two years in the middle of the 8th century BC, and Isaiah must have begun his ministry a few years before Uzziah's death, probably in the 740s BC. Isaiah lived until the fourteenth year of Hezekiah (who died 698 BC), and may have been contemporary for some years with Manasseh. Thus Isaiah may have prophesied for as long as sixty-four years.
Isaiah's wife was called "the prophetess" (Isaiah 8:3), either because she was endowed with the prophetic gift, like Deborah (Judges 4:4) and Huldah (2 Kings 22:14-20), or simply because she was the wife of "the prophet" (Isaiah 38:1). The second interpretation, that it was simply an honorary title, "Mrs. Prophet" as it were, is likely. They had two sons, naming one Shear-Jashub, meaning "A remnant shall return"Isaiah 7:3 and the younger, Maher-Shalal-Hash-Baz, meaning, "Spoil quickly, plunder speedily."Isaiah 8:3
In early youth, Isaiah may have been moved by the invasion of Israel by the Assyrian monarch Tiglath-Pileser III (2 Kings 15:19); and again, twenty years later, when he had already entered on his office, by the invasion of Tiglath-Pileser and his career of conquest. Ahaz, king of Judah, at this crisis refused to co-operate with the kings of Israel and Syria in opposition to the Assyrians, and was on that account attacked and defeated by Rezin of Damascus and Pekah of Israel (2 Kings 16:5; 2 Chronicles 28:5–6). Ahaz, thus humbled, sided with Assyria, and sought the aid of Tiglath-Pileser against Israel and Syria. The consequence was that Rezin and Pekah were conquered and many of the people carried captive to Assyria (2 Kings 15:29, 16:9; 1 Chronicles 5:26).
Soon after this Shalmaneser V determined wholly to subdue the kingdom of Israel, Samaria was taken and destroyed (722 BC). So long as Ahaz reigned, the kingdom of Judah was unmolested by the Assyrian power; but on his accession to the throne, Hezekiah, who was encouraged to rebel "against the king of Assyria" (2 Kings 18:7), entered into an alliance with the king of Egypt (Isaiah 30:2–4). This led the king of Assyria to threaten the king of Judah, and at length to invade the land. Sennacherib (701 BC) led a powerful army into Judah. Hezekiah was reduced to despair, and submitted to the Assyrians (2 Kings 18:14–16). But after a brief interval war broke out again, and again Sennacherib led an army into Judah, one detachment of which threatened Jerusalem (Isaiah 36:2–22; 37:8). Isaiah on that occasion encouraged Hezekiah to resist the Assyrians (37:1–7), whereupon Sennacherib sent a threatening letter to Hezekiah, which he "spread before the LORD" (37:14).
Then Isaiah the son of Amoz sent to Hezekiah, saying, Thus saith the LORD God of Israel, That which thou hast prayed to me against Sennacherib king of Assyria I have heard.
This is the word that the LORD hath spoken concerning him; the virgin the daughter of Zion hath despised thee, and laughed thee to scorn; the daughter of Jerusalem hath shaken her head at thee.
Whom hast thou reproached and blasphemed? and against whom hast thou exalted thy voice, and lifted up thine eyes on high? even against the Holy One of Israel.
According to the account in Kings (and its derivative account in Chronicles) the judgment of God now fell on the Assyrian army and wiped out 180,000 of its men. "Like Xerxes in Greece, Sennacherib never recovered from the shock of the disaster in Judah. He made no more expeditions against either southern Palestine or Egypt."
The remaining years of Hezekiah's reign were peaceful (2 Chr 32:23–29). Isaiah probably lived to its close, and possibly into the reign of Manasseh, but the time and manner of his death are not specified in either the Bible or recorded history. There is a tradition (reported in both the Martyrdom of Isaiah and the Lives of the Prophets) that he suffered martyrdom by Manasseh due to pagan reaction.
Gregory of Nyssa, believed that the Prophet Esaias (Isaiah) "knew more perfectly than all others the mystery of the religion of the Gospel." Jerome also lauds the Prophet Esias, saying, "He was more of an Evangelist than a Prophet, because he described all of the Mysteries of the Church of Christ so vividly that you would assume he was not prophesying about the future, but rather was composing a history of past events."